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Evaluation of Moore et al 's Distance Method over Fulco et al CRISPRi-FlowFISH validation dataset

Objectives

Our objectives were:

  • to ensure the AUPR of the Distance method remains approximately the same when we intersect the CRISPRi-FlowFISH validation dataset with ccRE (as Moore et al 's Distance method takes ccRE only as candidate regions)
  • to compute predictions with Distance method to later use them as input for the Average rank method

See detailed procedure here.

Results

Image: Precision-Recall curves and AUPR of Moore et al's Distance method over Fulco et al validation dataset intersected with ccRE

Precision-Recall curves and AUPR of Moore et al's Distance method over Fulco et al validation dataset intersected with ccRE (103 positives and 3569 negatives).